Tag Archives: Graft versus host

What’s eating at you?

 

The doctors said the Graft Versus Host Disease symptoms could return at random anytime during the next ten years as the new host DNA grafted cells continue to fight with my host cells. Well, it did come back. While a maddening nuisance, it’s not medically significant. It’s like a thousand ants nibbling at the skin from the top of the head to the sole of the feet. In a moment of respite, I’m reminded of other things that “eat” at us all.

 

Do you find yourself getting frustrated at small things? We get frustrated with ourselves, frustrated with others, frustrated with things that don’t work, frustrated with the fast pace of life, and frustrated with the times we’re stuck in a holding pattern. We huff and puff,  sigh deeply,  clench our muscles, and frown. Sometimes words not meant to be said get spoken.  But it’s not like going into a full rage that requires anger management therapy, so it’s no big deal, right? Or is it?

 

Decades ago, I read a book on stress management by a physician who asserted that getting upset at small things is indeed a big deal.   Certainly, there is much damage that can be done by the big stressors in life:  death of a loved one, a serious illness, abusive and neglectful relationships, or chronic pain or nearly any big loss. But the doctor warned that it is the accumulation of small things that really attack our bodies. He described the chemical interactions that occur in the body and mind when we experience unproductive stress and explained how this takes its toll over the years. He theorized that each negative expression of frustration could actually shorten our life by up to thirty seconds.  If you find yourself getting frustrated ten times a day that’s five minutes. That’s an hour over the course of two weeks; more than a whole day over a year. Imagine, at the end of your life, wanting to have another hour or another day with your loved ones.

 

The doctor related that studies reveal even the memory of stressed events triggers these same chemical reactions. It seems the cells in our bodies are always listening to what’s going on around them and always ready to respond. This is a good thing because it allows us to react quickly to truly stressful situations. But when the response is unproductive such as negative thinking and worry, the effect on the body is harmful. Interestingly, the opposite is true. When our body is at rest and our mind contemplates positive thoughts, the chemical reactions have restorative properties.

 

The bible’s many warnings about worrying and thinking bad thoughts is not just about wasted time. It’s about negative affects on our minds and bodies. It’s time we discipline ourselves to think and act better. Demand less. Practice being calm in the face of frustration. Seek God’s presence in those moments and find the peace his perspective brings. Read scripture to regularly renew your mind. You won’t be perfect at this, but over time you’ll be amazed at the difference it makes in your life. And your loved ones will thank you.

 

 

Medical Update: What would you do without an experienced guide?

This morning as I was unable to sleep, I found myself thinking back on the white water rafting trip our family took in Colorado years ago. As first time rafters, we were both excited and apprehensive about the moment by moment thrills of the experience. Our experienced guide, having been down this river many times, had both the mindset of being calm – because he knew what was around the bend – and also vigilant, because he knew the potential dangers that could arise at any moment. That’s how it is with me and my medical team. Being my first (and hopefully only) time down this river, I tend to see things through the experience of my current symptoms. My experienced and caring medical team is concerned with saving my life. The team agrees that my recovery is well ahead of the curve (thank you God and prayer partners!); but they have their eyes somberly set on what’s around the bend, especially in the next 6-18 months. This is the time it will take for my body to fully rebuild the immune system and regain strength and deal with oncoming threats.

An interesting component of the treatment plan is that while the goal is to grow the immune system, the approach is actually to suppress it in the beginning so my donor cells don’t attack my body. This is called Graft Versus Host Disease (GVHD) and was what led to my Failure To Thrive diagnosis the three summer months when I couldn’t eat or get much beyond bed or recliner. So I take daily medications to prevent my immune system from functioning even as optimally as it could with currently limited resources. The team monitors the degree of ‘fighting’ that goes on in my body, trying to maintain a balance. Some fighting is good; too much is dangerous. Gradually, they will reduce the suppressing medications to let my body take on more of the fight on its own. I am also working to get off the steroids that have helped me overcome the Failure to Thrive condition but have also wreaked havoc with other mental and physical functioning. Nearly seven months post stem cell transplant, I still make trips every two weeks to the U of I Hospitals for blood tests, lung treatments and follow-up consultation.

What’s around the bend? Continual protection against infections and increasing endurance and strength, and hopefully regain mental capacity; and trusting our loving God to guide us through the waters as we also journey into our new mission field. It is an amazing journey! I pray yours will be less dramatic but no less exciting and rewarding.